Joshua L Dunaief Selected Research

Iron

6/2022	Reduction in Ferritin Concentrations among Patients Consuming a Dark-Green Leafy Vegetable-Rich, Low Inflammatory Foods Everyday (LIFE) Diet.
1/2022	Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis.
1/2022	Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload.
1/2022	Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction.
1/2022	Minimal effect of conditional ferroportin KO in the neural retina implicates ferrous iron in retinal iron overload and degeneration.
11/2021	Intraocular iron injection induces oxidative stress followed by elements of geographic atrophy and sympathetic ophthalmia.
6/2020	Bull's eye maculopathy associated with hereditary hemochromatosis.
1/2020	Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE autofluorescence.
1/2020	Oral administration of the iron chelator deferiprone protects against loss of retinal ganglion cells in a mouse model of glaucoma.
12/2019	Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis.

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Joshua L Dunaief Research Topics

Disease

46	Macular Degeneration (Age-Related Maculopathy) 01/2022 - 05/2003
27	Iron Overload 06/2022 - 09/2004
27	Retinal Degeneration 01/2022 - 04/2003
11	Inflammation (Inflammations) 06/2022 - 08/2004
11	Retinal Diseases 01/2022 - 09/2004
10	Geographic Atrophy 01/2022 - 05/2003
9	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2019 - 08/2004
6	Hypertrophy 01/2019 - 09/2004
5	Blindness (Hysterical Blindness) 01/2022 - 03/2011
4	Choroidal Neovascularization 11/2021 - 09/2008
4	Glaucoma 08/2021 - 11/2007
4	Hemorrhage 10/2019 - 10/2007
4	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 05/2003
3	Hemochromatosis (Bronze Diabetes) 06/2020 - 11/2006
3	Anemia 10/2019 - 09/2009
3	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 10/2019 - 09/2009
3	Atrophy 01/2019 - 06/2005
3	Friedreich Ataxia (Friedreich's Ataxia) 10/2018 - 11/2007
3	Inborn Genetic Diseases (Disease, Hereditary) 10/2018 - 11/2006
3	Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease) 10/2018 - 10/2007
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 01/2017
2	Ocular Hypertension (Glaucoma, Suspect) 11/2020 - 01/2020
2	Siderosis 01/2020 - 10/2007
2	Multiple Sclerosis 01/2020 - 12/2019
2	Optic Nerve Diseases (Optic Neuropathy) 12/2019 - 07/2009
2	Disease Progression 01/2019 - 10/2004
2	Thrombosis (Thrombus) 01/2019 - 01/2019
2	Tauopathies 01/2019 - 10/2017
2	Eye Diseases (Eye Disease) 01/2016 - 07/2009
2	Iron Deficiencies 01/2014 - 11/2007
2	Hyperplasia 06/2008 - 09/2004
1	Parkinson Disease (Parkinson's Disease) 01/2022
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 11/2021
1	Migraine Disorders (Migraine) 11/2021
1	Dementia (Dementias) 11/2021
1	Chronic Disease (Chronic Diseases) 11/2021
1	Sympathetic Ophthalmia (Sympathetic Uveitis) 11/2021
1	Neuroinflammatory Diseases 08/2021
1	Type 2 Diabetes Mellitus (MODY) 08/2021
1	Retinal Dystrophies 06/2020
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2019
1	Optic Neuritis (Retrobulbar Neuritis) 12/2019
1	Hypertension (High Blood Pressure) 10/2019
1	Cicatrix (Scar) 01/2019
1	Myopia 01/2019

Drug/Important Bio-Agent (IBA)

54	IronIBA 06/2022 - 08/2003
43	Retinaldehyde (Retinal)IBA 01/2022 - 04/2003
12	Ceruloplasmin (Ferroxidase)IBA 01/2022 - 04/2003
12	Familial apoceruloplasmin deficiencyIBA 10/2018 - 09/2004
11	Chelating AgentsIBA 11/2021 - 07/2009
9	Proteins (Proteins, Gene)FDA Link 06/2022 - 08/2004
8	Complement System Proteins (Complement)IBA 01/2020 - 01/2012
7	AntioxidantsIBA 11/2021 - 08/2004
7	DeferiproneIBA 01/2020 - 02/2011
6	Isoflurophate (DFP)FDA Link 01/2020 - 02/2011
4	Messenger RNA (mRNA)IBA 01/2022 - 08/2014
4	LipofuscinIBA 01/2019 - 11/2006
3	Ferritins (Ferritin)IBA 06/2022 - 12/2005
3	Biomarkers (Surrogate Marker)IBA 11/2021 - 10/2017
3	A-factor (Streptomyces)IBA 01/2019 - 11/2006
2	Retinal Pigments (Pigments, Visual)IBA 01/2022 - 01/2016
2	metal transporting protein 1 (ferroportin)IBA 01/2022 - 12/2005
2	Glucagon-Like Peptide-1 ReceptorIBA 08/2021 - 11/2020
2	Indicators and Reagents (Reagents)IBA 01/2021 - 01/2021
2	Thioctic Acid (Lipoic Acid)IBA 01/2020 - 01/2016
2	Amyloid (Amyloid Fibrils)IBA 01/2019 - 10/2017
2	Complement Factor H (Factor H)IBA 01/2019 - 01/2019
2	EnzymesIBA 01/2019 - 01/2016
2	CopperIBA 01/2018 - 07/2006
2	InflammasomesIBA 06/2015 - 05/2012
2	Transcription Factors (Transcription Factor)IBA 11/2014 - 08/2004
2	RNA (Ribonucleic Acid)IBA 05/2012 - 03/2011
2	Heme Oxygenase-1IBA 01/2012 - 01/2012
2	sodium iodateIBA 01/2012 - 01/2012
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 06/2022
1	PhytochemicalsIBA 06/2022
1	SynucleinsIBA 01/2022
1	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2022
1	DeuteriumIBA 01/2022
1	Transferrin Receptors (Transferrin Receptor)IBA 01/2022
1	Docosahexaenoic AcidsIBA 01/2022
1	C-Reactive ProteinIBA 11/2021
1	ferric ammonium citrate FDA Link 11/2021
1	Blood Glucose (Blood Sugar)IBA 08/2021
1	Ranibizumab (Lucentis)FDA Link 07/2021
1	Bevacizumab (Avastin)FDA Link 07/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2020
1	CytokinesIBA 11/2020
1	compstatinIBA 01/2020
1	MetalsIBA 12/2019
1	Monomeric GTP-Binding ProteinsIBA 12/2019
1	Glutamic Acid (Glutamate)FDA Link 12/2019
1	AnticoagulantsIBA 10/2019
1	Dextrans (Dextran)FDA Link 10/2019
1	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 01/2019

Therapy/Procedure

8	Therapeutics 01/2022 - 11/2006
1	Plant-Based Diet 06/2022
1	Microspheres (Microsphere) 01/2020
1	Injections 01/2020
1	Oral Administration 01/2020